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Search Results for " renal fibrosis "

ターゲット

19

阻害剤

6

天然化合物

18

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T13865 Resorcinolnaphthalein RAAS
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).
T12883 Fezagepras PBI-4050,Setogepram GPR
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.
T4583 PFI-2 hydrochloride (R)-PFI-2 hydrochloride,PFI-2 HCl Histone Methyltransferase
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.
T16708 R-268712 ALK , TGF-beta/Smad
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.
T1987 PFI-2 PFI2,PFI 2,(R)-PFI-2 Histone Methyltransferase
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
T14076 A 839977 A839977,A-839977 P2X Receptor , Calcium Channel
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis.
T16886 Sinefungin Adenosyl-Ornithine,A-9145,Antibiotic 32232RP Others , Histone Methyltransferase , Antibiotic , Antifungal
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r...
T9953 BT173 Others
BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.
T24270 KS370G KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s...
T15300 Fluorofenidone AKF-PD Others
Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...
T80072 Des-Arg9-[Leu8]-Bradykinin acetate Bradykinin Receptor
Des-Arg9-[Leu8]-Bradykinin acetate is a potent antagonist of the bradykinin receptor 1 (B1R), utilized in renal fibrosis research [1].
T79516 BT424 Src
BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].
T70932 L6H9
L6H9 is a novel inhibitor of myeloid differentiation factor 2 (MD2), suppressing HG-induced expression of ACE and AT1 receptor and Angiotensin II (AngII) production in renal NRK‐52E cells, resulting in the decrease in fi...
T73088 Mavodelpar HPP593,REN001,REN001 ; HPP593
Mavodelpar (REN001), a selective PPARδ agonist, effectively suppresses glomerular injury and renal fibrosis. It is utilized in the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation di...
T62909 SGC agonist 2
SGC agonist 2 is a potent soluble guanylate cyclase (SGC) agonist. SGC agonist 2 has potential for cardiovascular disease (heart failure, angina, pulmonary hypertension, myocardial infarction) and fibrotic disease (renal...
T61949 Evogliptin
Evogliptin (DA-1229) is a DPP4 inhibitor with oral activity. Evogliptin has significant and lasting hypoglycemic effect in mouse model. Evogliptin inhibits the production of the fibrosis and inflammatory in hepatocytes s...
T83770 Klotho-derived Peptide 1 (56-87) (human) TFA KP1 (56-87)
Klotho-derived peptide 1 (KP1) (56-87), a peptide originating from the human Klotho protein, disrupts TGF-β signaling by binding to TGF-β receptor types 1 and 2 (TGFBR1 and TGFBR2; Kds = 1.41 and 14.6 µM, respectively). ...
T74142 Angiotensin II human TFA
Angiotensin II human TFA, a potent vasoconstrictor within the renin/angiotensin system, plays a pivotal role in human blood pressure regulation primarily through interactions with the G-protein-coupled receptors Angioten...
T36673 CC 401 dihydrochloride
High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase...
カタログ番号 製品名 別名 ターゲット
T3033 Deoxycorticosterone acetate DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
T3S1227 Aristolactam I Aristolactam,Aristololactam I,Aristololactum Apoptosis , Caspase
1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF...
T2S2043 Dracorhodin perchlorate Dracorhodin perochlorate,Dracohodin perochlorate Apoptosis , Others
Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate...
T72798 Ganodermaones B
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .
TN3753 Dalbergioidin Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or...
TMA1743 Ergosterol peroxide ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-03014 Osteoactivin/GPNMB Protein, Mouse, Recombinant (His) Mouse HEK293
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteocla...
TMPY-05053 ANGPTL2 Protein, Human, Recombinant (His) Human HEK293
The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
TMPK-00138 CXCL16 Protein, Mouse, Recombinant (hFc) Mouse HEK293
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall c...
TMPK-00526 LRG1 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular...
TMPK-00469 CXCL16 Protein, Human, Recombinant (hFc) Human HEK293
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall c...
TMPK-01128 LRG1 Protein, Mouse, Recombinant (His) Mouse HEK293
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular...
TMPK-01225 MRC2 Protein, Human, Recombinant (His) Human HEK293
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellu...
TMPK-00574 MRC2 Protein, Canine, Recombinant (His) Canine HEK293
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellu...
TMPK-00973 Periostin/OSF-2 Protein, Human, Recombinant (aa 22-836, His) Human HEK293
Periostin is a matricellular protein that is expressed in several tissues during embryonic development; however, its expression in adults is mostly restricted to collagen-rich connective tissues. Periostin is expressed o...
TMPK-01032 Periostin/OSF-2 Protein, Mouse, Recombinant (aa 24-811, His) Mouse HEK293
Periostin is a matricellular protein that is expressed in several tissues during embryonic development; however, its expression in adults is mostly restricted to collagen-rich connective tissues. Periostin is expressed o...
TMPY-03402 Osteoactivin/GPNMB Protein, Human, Recombinant (hFc) Human HEK293
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteocla...
TMPY-02143 Osteoactivin/GPNMB Protein, Human, Recombinant (His) Human HEK293
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteocla...
TMPY-01826 Relaxin 1/RLN1 Protein, Human, Recombinant (His) Human HEK293
Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein that belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductiv...
TMPJ-00332 TPA Protein, Human, Recombinant (His) Human Human Cells
Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs...
TMPY-02898 TPA Protein, Mouse, Recombinant (hFc) Mouse HEK293
Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-00937 TPA Protein, Human, Recombinant (hFc) Human HEK293
Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-00938 TPA Protein, Human, Recombinant Human HEK293
Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-03998 ANGPTL2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
Osteoactivin/GPNMB Protein, Mouse, Recombinant (His)
TMPY-03014
Species: Mouse
Expression System: HEK293
ANGPTL2 Protein, Human, Recombinant (His)
TMPY-05053
Species: Human
Expression System: HEK293
CXCL16 Protein, Mouse, Recombinant (hFc)
TMPK-00138
Species: Mouse
Expression System: HEK293
LRG1 Protein, Cynomolgus, Recombinant (His)
TMPK-00526
Species: Cynomolgus
Expression System: HEK293
CXCL16 Protein, Human, Recombinant (hFc)
TMPK-00469
Species: Human
Expression System: HEK293
LRG1 Protein, Mouse, Recombinant (His)
TMPK-01128
Species: Mouse
Expression System: HEK293
MRC2 Protein, Human, Recombinant (His)
TMPK-01225
Species: Human
Expression System: HEK293
MRC2 Protein, Canine, Recombinant (His)
TMPK-00574
Species: Canine
Expression System: HEK293
Periostin/OSF-2 Protein, Human, Recombinant (aa 22-836, His)
TMPK-00973
Species: Human
Expression System: HEK293
Periostin/OSF-2 Protein, Mouse, Recombinant (aa 24-811, His)
TMPK-01032
Species: Mouse
Expression System: HEK293
Osteoactivin/GPNMB Protein, Human, Recombinant (hFc)
TMPY-03402
Species: Human
Expression System: HEK293
Osteoactivin/GPNMB Protein, Human, Recombinant (His)
TMPY-02143
Species: Human
Expression System: HEK293
Relaxin 1/RLN1 Protein, Human, Recombinant (His)
TMPY-01826
Species: Human
Expression System: HEK293
tPA Protein, Human, Recombinant (His)
TMPJ-00332
Species: Human
Expression System: Human Cells
tPA Protein, Mouse, Recombinant (hFc)
TMPY-02898
Species: Mouse
Expression System: HEK293
tPA Protein, Human, Recombinant (hFc)
TMPY-00937
Species: Human
Expression System: HEK293
tPA Protein, Human, Recombinant
TMPY-00938
Species: Human
Expression System: HEK293
ANGPTL2 Protein, Mouse, Recombinant (hFc)
TMPY-03998
Species: Mouse
Expression System: HEK293